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Cephalosporinsincluding Supraxmay be associated with a fall in prothrombin activityThose at risk include patients with renal or hepatic impairmentor poor nutritional stateas well as patients receiving a protracted course of antimicrobial therapyand patients previously stabilized on anticoagulant therapyProthrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated.

Otitis media should be treated with the chewable tablets or suspensionClinical trials of otitis media were conducted with the chewable tablets or suspensionand the chewable tablets or suspension results in higher peak blood levels than the tablet when administered at the same dose.

Phenylalanine can be harmful to patients with phenylketonuriaPKUchewable tablets contain aspartamea source of phenylalaninebefore prescribingconsider combined daily amount of phenylalanine from all sourcesincluding chewable tablets.

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